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A few examples are microglia in the brain, Kupffer cells in the liver, and alveolar macrophages in the lungs (Davies et al.
, surfactant in alveolar macrophages and red blood cells in Kupffer cells), initiation of the inflammatory response and the return to homeostasis.
Indeed, silencing of HIF-1a expression mark- edly decreases TGFb1 production in alveolar macrophages and attenuates the development of bleomycin-induced fibrosis, con- firming a critical role for TGF-b1-producing macrophages in the development of fibrosis in response to bleomycin.
Alveolar macrophages transmit key signals to neighboring cells to help facilitate the resolution of inflammation in the lung.
(A) After LPS inhalation, a specialized population of sessile alveolar macrophages attached to the alveolar wall form gap-junction channels with the epithelium.
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